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ea0019oc20 | Cardiovascular metabolism | SFEBES2009

The novel peptide prokineticin-2 potently inhibits food intake in rodents and is a potential novel anti-obesity therapy

Bataveljic A , Gardiner J , Patel N , Bewick G , Roy D , Cooke J , Campbell D , Semjonous N , Murphy K , Hameed S , Prosser H , Jethwa P , Ebling F , Vickers S , Cheetham S , Maleuwe P , Ghatei M , Bloom S , Dhillo W

Background: The novel peptide prokineticin-2 (PK2) has recently been implicated in the regulation of a number of physiological processes; including regulating gastrointestinal motility, spermatogenesis, neurogenesis and circadian rhythms. PK2 is a cysteine rich protein which mediates its effects via the prokineticin receptors which are expressed in several hypothalamic nuclei known to regulate food intake. We therefore hypothesised that PK2 may be an important endogenous regul...

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Endocrine Abstracts

The novel peptide prokineticin-2 potently inhibits food intake in rodents and is a potential novel anti-obesity therapy

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